| 蔗糖铁注射液铁含量测定方法的研究 |
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| 引用本文： | 李 莉,汪一帆,花传政. 蔗糖铁注射液铁含量测定方法的研究[J]. 药学与临床研究, 2011, 19(5): 414-416 |
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| 作者姓名： | 李 莉 汪一帆 花传政 |
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| 作者单位： | 南京医科大学第二附属医院,南京,210011 |
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| 摘 要： | 蔗糖铁注射液是一种静脉铁注射剂,用以治疗缺铁性贫血。本文对比了原子吸收光谱法、氧化还原滴定法和络合滴定法,并对选用的络合滴定条件进行了全面考察。在盐酸和过氧化氢溶液的作用下,用氢氧化钠溶液调节pH至2.2~2.5,加Tiron指示剂,用乙二胺四醋酸二钠滴定液滴定至溶液显纯黄色,并计算铁含量。试验结果表明其精密度好,准确度高,成本低,是一种适合蔗糖铁注射液铁含量测定的方法。
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| 关 键 词： | 蔗糖铁注射液 原子吸收法 络合滴定 氧化还原滴定 |
| 收稿时间： | 2011-05-11 |
| 修稿时间： | 2011-06-30 |
Research on Content Determination of Iron in Iron Sucrose Injection |
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| LI Li,WANG Yi-fan and HUA Chuan-zheng. Research on Content Determination of Iron in Iron Sucrose Injection[J]. Pharmacertical and Clinical Research, 2011, 19(5): 414-416 |
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| Authors: | LI Li WANG Yi-fan HUA Chuan-zheng |
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| Affiliation: | LI Li,WANG Yi-fan,HUA Chuan-zheng The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China |
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| Abstract: | Iron Sucrose Injection is a kind of intravenous iron injection that is used for treatment of iron-deficiency anemia.Three methods for content determination of iron in the iron sucrose injection-atomic absorption spectrometry,oxidation-reduction titration and EDTA complexometric titration were compared.The influence factors on EDTA complexometric titration method-pH,volume of HCl,H2O2 and indicator were investigated.The result showed that the EDTA complexometric titration has good accuracy,high precision and... |
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| Keywords: | Iron sucrose injection AAS Complexometric titration Oxidation-reduction titration |
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