| 复方首乌软胶囊对D-半乳糖致亚急性衰老小鼠p16基因表达的影响 |
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| 引用本文： | 姚 毅,谭喜莹,王淑云,朱萱萱. 复方首乌软胶囊对D-半乳糖致亚急性衰老小鼠p16基因表达的影响[J]. 药学与临床研究, 2011, 19(5): 411-413 |
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| 作者姓名： | 姚 毅 谭喜莹 王淑云 朱萱萱 |
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| 作者单位： | 江苏省中医院,南京,210029 |
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| 基金项目： | 江苏省中医药管理局基金 |
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| 摘 要： | 目的:研究复方首乌软胶囊对衰老小鼠p16基因表达的影响,探讨复方首乌软胶囊的抗衰老机制。方法:用D-半乳糖建立衰老小鼠模型,以复方首乌软胶囊治疗,实时荧光定量PCR法观察小鼠脑海马p16基因的mRNA表达。结果:复方首乌软胶囊组p16基因mRNA表达降低。结论:复方首乌软胶囊能降低p16基因的表达,从而起到抗衰老作用。
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| 关 键 词： | 复方首乌软胶囊 衰老 p16基因表达 |
| 收稿时间： | 2011-05-29 |
| 修稿时间： | 2011-07-15 |
Effects of Shouwu Soft Capsules on p16 Gene Expression of D-Galactose-induced Subacute Aging Mice |
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| YAO Yi,TAN Xi-ying,WANG Shu-yun and ZHU Xuan-xuan. Effects of Shouwu Soft Capsules on p16 Gene Expression of D-Galactose-induced Subacute Aging Mice[J]. Pharmacertical and Clinical Research, 2011, 19(5): 411-413 |
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| Authors: | YAO Yi TAN Xi-ying WANG Shu-yun ZHU Xuan-xuan |
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| Affiliation: | YAO Yi,TAN Xi-ying,WANG Shu-yun,ZHU Xuan-xuan Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210029,China |
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| Abstract: | Objective: To study the effects of Shouwu Soft Capsules on p16 gene expression in D-galactose-induced subacute aging mice.Methods: The mice was injected with D-galactose to built the model of aging and then treated with Shouwu Soft Capsules,the mRNA expression of p16 gene in brain was observed.Results: mRNA expression of p16 gene in Shouwu Soft Capsules groups was decreased.Conclusion: Shouwu Soft Capsules can decrease the expression of p16 gene and have antiaging actions. |
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| Keywords: | Shouwu Soft Capsules Aging p16 gene expression |
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