| 钆喷酸葡胺脂质体在小鼠体内的分布与药代动力学 |
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| 引用本文： | 李铁福,王雨青,金杰,刘晶莹.钆喷酸葡胺脂质体在小鼠体内的分布与药代动力学[J].沈阳药科大学学报,2003,20(6):402-404,434. |
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| 作者姓名： | 李铁福 王雨青 金杰 刘晶莹 |
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| 作者单位： | 沈阳药科大学制药工程学院,辽宁沈阳,110016 |
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| 摘 要： | 目的研究钆喷酸葡胺脂质体在小鼠体内的分布与药代动力学。方法应用ICP发射光谱分析法定量测定了钆喷酸葡胺及其脂质体在小鼠心、肝、脾、肺、肾及血中的钆浓度。结果钆喷酸葡胺及其脂质体在小鼠体内的血药时程变化符合二室模型。钆喷酸葡胺脂质体保持了相对较高的血药浓度 ,并且在肝脾中的分布明显增加。结论钆喷酸葡胺脂质体具有肝脾靶向性
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| 关 键 词： | 钆喷酸葡胺 靶向 分布 药代动力学 |
| 文章编号： | 1006-2858(2003)06-0402-03 |
Distribution and pharmacokinetics of Gd-DTPA liposomes in mice |
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| LI Tie-fu,WANG Yu-qing,JIN Jie,LIU Jing-ying.Distribution and pharmacokinetics of Gd-DTPA liposomes in mice[J].Journal of Shenyang Pharmaceutical University,2003,20(6):402-404,434. |
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| Authors: | LI Tie-fu WANG Yu-qing JIN Jie LIU Jing-ying |
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| Abstract: | Objective To study the distribution and pharmacokinetics of Gd-DTPA and Lip Gd-DTPA in mice.Methods The tissue and blood concentration of Gd-DTPA and Lip Gd-DTPA in mice were determined by ICP-AES.Results The concentration time curves of them in mice could be fitted to two compartment open models.LipGd-DTPA maintained a higher level of blood drug concentration compared with that of Gd-DTPA,and the distribution of it in the liver and spleen were enhanced evidently.Conclusion LipGd-DTPA has targeting to the liver and spleen evidently. |
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| Keywords: | Gd-DTPA targeting distribution pharmacokinetics |
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