| 山茱萸总甙抑制免疫的体内效应及其对移植心脏存活的延长 |
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| 引用本文： | 赵武述,李洁,张玉琴,丛笑,赵世萍,薛智.山茱萸总甙抑制免疫的体内效应及其对移植心脏存活的延长[J].中华微生物学和免疫学杂志,1995(5). |
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| 作者姓名： | 赵武述 李洁 张玉琴 丛笑 赵世萍 薛智 |
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| 作者单位： | 中日友好临床医学研究所免疫室，中日友好临床医学研究所免疫室，中日友好临床医学研究所免疫室，中日友好临床医学研究所免疫室，中日友好临床医学研究所药物药理室，中日友好临床医学研究所药物药理室 100029 北京，100029 北京，100029 北京，100029 北京，100029 北京，100029 北京 |
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| 摘 要： | 腹腔注射山茱萸总甙(COG)50mg/kg·d×5和100mg/kg·d×5,小鼠淋巴细胞产生白细胞介素2(IL—2),分别由2.28±0.48U/ml下降为1.65±0.29U/ml和0.90±0.20U/ml。小鼠的MLR也因预先注射COG而显著下降。小鼠移植心脏存活时间,在COG治疗组由9.2±1.2天延长到17.4±6.7天,而且COG可在环孢霉素A(CsA)10mg/kg·d×4基础上,由15.0±1.6天延长到19.0±3.2天。
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| 关 键 词： | 山茱萸 总甙 免疫抑制 移植 |
IN VIVO IMMUNOSUPPRESSIVE EFFECT OF CORNUS OFFICINALIS GLYCOSIDES AND THEIR ACTIVITY ON PROLONGATING THE SURVIVAL OF TRANSPLANTATED MICE HEARTS |
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| Zhao Wushu. Li Jie,Zhang Yuqin,et al.IN VIVO IMMUNOSUPPRESSIVE EFFECT OF CORNUS OFFICINALIS GLYCOSIDES AND THEIR ACTIVITY ON PROLONGATING THE SURVIVAL OF TRANSPLANTATED MICE HEARTS[J].Chinese Journal of Microbiology and Immunology,1995(5). |
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| Authors: | Zhao Wushu Li Jie Zhang Yuqin |
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| Institution: | Zhao Wushu. Li Jie,Zhang Yuqin,et al Department of Immunology,China-Japan Friendship Institute of Clinical Medical Sciences,Beijing 100029 |
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| Abstract: | After intraperitoneal injection of Cornus officinalis glycosides (COG) into mouse with a dose of 50mg/kg.dX5, LPS-induced lymphocyte blasts significantly decreased. The interleukin 2(IL-2) levels produced by mouse splenic lymphocytes in COG 50mg/kg-dX5 and 100mg/kg-dX5 groups,declined from 2. 28 0.48U/ml to 1. 65 0. 29U/ml and to 0.90 0.20U/ml,respectively. Mouse mixed lymphocytes reaction (MLR) were suppressed owing to preliminary administration of COG. The survival span of transplantated mice hearts (BALB/c-NIH mouse) prolongated from 9. 2 1. 2 days to 17. 4 6. 7 days in treated group with COG 400mg/kg.d X16. Furthermore,based upon administration of Cyclosporin A(CsA) l0mg/kg.d X 4,COG the survival span prolongated from 15.0 l.6 days to 19. 0 3.2 days. |
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| Keywords: | Cornusofficinalis Glycosides I mmunosuppression Transplantation |
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