奥曲肽及其类似物用于肿瘤诊断的进展

简要综述111In-奥曲肽和99Tcm-NeoTec在肿瘤诊断中的应用,其对类癌、甲状腺髓样癌、来自胰腺或上消化道的神经内分泌肿瘤的诊断和随访有重要价值,对失去摄碘功能的分化型甲状腺癌、甲亢性突眼、肉样瘤病的肉芽肿过程也可得到阳性结果。应用放射性核素标记的生长抑素类似物使肿瘤成功的显像,可发展并应用标记的类似物来治疗这些肿瘤。生长抑素类似物的标记技术扩展了应用其他肽类进行分子显像的研究兴趣。

Advances in tumor diagnosis with labeled somatostatin analogues

Values of 111 In-octreotide and 99 Tc m -NeoTec in tumor diagnosis are briefly reviewed.There are great values in diagnosis and follow up for patients with carcinoid tumor,medullary cancer of thyroid,and neuroendocrine tumors from pancreas or upper respiratory tract.Somatostatin receptors are also distributed in organs outside the classical neuroendocrine tissues.Positive studies are also found in patients with differentiated cancer of thyroid whose tuor have lost iodide concentrating ability,exophthalmos in Graves' disease or granulomatous process in sarcoidosis.The successes of tumor imaging with labeled somatostatin analogues have led to the development of radionuclide therapy for these tumors with the labeled analogues.The technics in labeling of somatostatin analogues have also led the expanded interests and studies of other peptides in molecular imaging.