首页 | 本学科首页   官方微博 | 高级检索  
     

Hepatic stem cells: existence and origin
引用本文:Zhang Y,Bai XF,Huang CX. Hepatic stem cells: existence and origin[J]. World journal of gastroenterology : WJG, 2003, 9(2): 201-204. DOI: 10.3748/wjg.v9.i2.201
作者姓名:Zhang Y  Bai XF  Huang CX
作者单位:The center of diagnosis and treatment for infectious diseases of PLA, Tang DuHospital, Fourth Military Medical University, Xi'an 710038, ShaanxiProvince, China 
摘    要:Stem cells are not only units of biological organization,responsible for the development and the regeneration of tissue and organ systems, but also are units in evolution by natural selection. It is accepted that there is stem cell potential in the liver. Like most organs in a healthy adult,the liver maintains a perfect balance between cell gain and loss. It has three levels of cells that can respond to loss of hepatocytes: (1) Mature hepatocytes, which proliferate after normal liver tissue renewal, less severe liver damage, etc;they are numerous, unipotent, “committed“ and respond rapidly to liver injury. (2) Oval cells, which are activated to proliferate when the liver damage is extensive and chronic,or if proliferation of hepatocytes is inhibited; they lie within or immediately adjacent to the canal of Hering (Coil); they are less numerous, bipotent and respond by longer, but still limited proliferation. (3) Exogenous liver stem cells, which may derive from circulating hematopoietic stem cells (HSCs) or bone marrow stem cells; they respond to allyl alcohol injury or hepatocarcinogenesis; they are multipotent, rare,but have a very long proliferation potential. They make a more significant contribution to regeneration, and even completely restore normal function in a murine model of hereditary tyrosinaemia. How these three stem cell populations integrate to achieve a homeostatic balance remains enigmatic. This review focuses on the location,activation, markers of the three candidates of liver stem cell, and the most importantly, therapeutic potential of hepatic stem cells.

关 键 词:肝干细胞  细胞起源  组织再生  细胞生物学  细胞疗法  肝疾病
收稿时间:2002-07-04

Hepatic stem cells: existence and origin
Zhang Ying,Bai Xue-Fan,Huang Chang-Xing. Hepatic stem cells: existence and origin[J]. World journal of gastroenterology : WJG, 2003, 9(2): 201-204. DOI: 10.3748/wjg.v9.i2.201
Authors:Zhang Ying  Bai Xue-Fan  Huang Chang-Xing
Affiliation:The center of diagnosis and treatment for infectious diseases of PLA, Tang DuHospital, Fourth Military Medical University, Xi'an 710038, ShaanxiProvince, China
Abstract:Stem cells are not only units of biological organization, responsible for the development and the regeneration of tissue and organ systems, but also are units in evolution by natural selection. It is accepted that there is stem cell potential in the liver. Like most organs in a healthy adult, the liver maintains a perfect balance between cell gain and loss. It has three levels of cells that can respond to loss of hepatocytes: (1) Mature hepatocytes, which proliferate after normal liver tissue renewal, less severe liver damage, etc; they are numerous, unipotent, "committed" and respond rapidly to liver injury. (2) Oval cells, which are activated to proliferate when the liver damage is extensive and chronic, or if proliferation of hepatocytes is inhibited; they lie within or immediately adjacent to the canal of Hering (CoH); they are less numerous, bipotent and respond by longer, but still limited proliferation. (3) Exogenous liver stem cells, which may derive from circulating hematopoietic stem cells (HSCs) or bone marrow stem cells; they respond to allyl alcohol injury or hepatocarcinogenesis; they are multipotent, rare, but have a very long proliferation potential. They make a more significant contribution to regeneration, and even completely restore normal function in a murine model of hereditary tyrosinaemia. How these three stem cell populations integrate to achieve a homeostatic balance remains enigmatic. This review focuses on the location, activation, markers of the three candidates of liver stem cell, and the most importantly, therapeutic potential of hepatic stem cells.
Keywords:
本文献已被 维普 万方数据 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号