2005～2007年重庆市巴南区医院500例菌株耐药性的临床分析

目的 探讨2005～2007年重庆市巴南区人民医院医院感染病原体的构成、临床分布特点及耐药谱的动态变化，以指导临床合理应用抗生素。方法采用VITEK微生物自动分析仪进行细菌鉴定并测定药敏，结果依据1999年NCCLS判断标准，对2005～2007年送检的各类标本所分离的菌株进行鉴定及药敏测定。结果 共收集临床分离菌500株，其中革兰阳性球菌150株，占30％，革兰阴性杆菌350株，占70％。分离菌株中以铜绿假单胞菌、大肠杆菌、金黄色葡萄球菌、肺炎克雷伯杆菌最多。结论 笔者所在医院患者中分离的细菌耐药性强且多重耐药，因此，应该了解各菌种的耐药特点和耐药机制，合理使用抗菌药物并严密监控新的耐药菌的产生。

Clinical analysis of the 500 examples of drug resistance for 2005 ～2007 in the people＇s hospital at Banan district of Chongqing

Objective To explore the compositions of nosocomial infection pathogene for 2005 ～ 2007 the distributing clinical features and the developing changes of drug resistant spectrum in People＇s Hospital at Banan district of Chongqing, to supply the guidance of making use of antibiotics reasonably at clinic. Methods Adopt the VITEK microorganism autoanalyser to carry out identification of bacteria and determine medicine agile, use the NCCLS judging standard in 1999 ,giving to identifying the separate strain from all kinds to carries out the specimen for 2005 -2007 and determining medicine agile. Results 500 examples collecting the clinical separation bacterium in total, the Gram positive cocci 150 among them accounting for 30%, and the Gram negative bacteria 350 among them accounting for 70%. In separating bacterium among them the Pseudmonas aeruginosa,Bacillus coli,Staphylococcus aureus,Klebsiella pneumoniae are the most. Conclusion The bacterium separating from the patient in this hospital,the bacterial drug resistance is strong and multidrug resistant, ought to know the drug fast characteristic and drug fast mechanism of all kinds of bacterium, rational use antibacterials and close supervisory control the new drug resistance bacteria creation.