Chronic imipramine treatment and weight gain |
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| Authors: | M H Fernstrom R L Krowinski D J Kupfer |
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| Affiliation: | 1. Division of Nephrology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan;2. Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;3. School of Public Health, National Defense Medical Center, Taipei, Taiwan;4. Taiwanese Injury Prevention and Safety Promotion Association, Taiwan;5. Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;6. Department of Microbiology & Immunology, National Defense Medical Center, Taiwan;1. Department of Psychiatry, Medical University of Gdańsk, Poland;2. Regional Epilepsy Outpatient Unit, Copernicus Hospital, Gdańsk, Poland |
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| Abstract: | A study of weight change in subjects treated with imipramine was performed on recurrent depressive outpatients. The patients (n = 52) were treated with imipramine (200-250 mg/day) and psychotherapy for 16 weeks. Each individual was weighed upon entry to the study (drug-free) and then weekly thereafter for 16 weeks. Of the 44 women (85%) and 8 men (15%) in the study, 60% of the total group had a weight gain or loss less than 5 pounds (mean = 1.1 pounds) over this time. A weight gain of 6-10 pounds was observed in 19% of subjects, while 9% of the group gained 11-15 pounds. Only 6% (3 subjects) gained more than 15 pounds. Three subjects (6%) lost 6-10 pounds. No correlations were observed between a change in weight and the subject's age, sex, prior weight, or response to medication. |
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