巨噬细胞自噬在动脉粥样硬化中的作用

自噬通过溶酶体依赖的降解途径维持细胞稳态。最新研究显示巨噬细胞自噬可以促进胆固醇流出,抑制炎症体活化从而抑制动脉粥样硬化进展。在进展期斑块内,巨噬细胞自噬水平降低,斑块易损性增高,极易导致斑块破裂,引起急性冠脉综合征。因此,调控巨噬细胞自噬已成为心血管领域的关注热点,深入探究其机理将为动脉粥样硬化的防治提供新思路。

The Effect of Macrophage Autophagy in Atherosclerosis

Autophagy is a lysosomal degradation pathway for cellular homeostasis. Recent research has shown that macrophage autophage inhibits progression of atherosclerosis by promoting efflux of cholesterol and restraining inflammasome activation. However macrophage autophagy is defective in the advanced plaques,which results in increasing of plaque vulnerability and risk of plaque rupture to cause acute coronary syndrome. Afterwards how to regulate the macrophage autophage in plaque turns out to be a hot spot in the management of atherosclerosis. Further investigation on the mechanism of macrophahe autophagy may provide new ideas for the prevention and treatment of atherosclerosis.