Notch1信号通路与血管钙化

Notch1信号通路是一个高度保守的信号转导通路,参与胚胎期血管的形成及发育以及出生后对损伤血管的修复等。血管钙化是羟基磷灰石在血管壁细胞的沉积,受多种调节因子、信号通路影响,是一个可主动调节、类似于骨形成的生物学过程。近年来研究表明Notch1信号通路与血管钙化存在密切关系。本文就Notch1信号通路的组成、效应传递及生理功能,血管钙化的发生机制及调节,以及Notch1信号通路与血管钙化的关系作一综述。

Notch1 Signaling Pathway and Vascular Calcification

Notch1 signaling pathway, as an evolutionarily conserved system of signal transduction, plays an important role in cardiovascular development and vascular repair throughout the embryonic period and postnatal day. Vascular calcification results not from a passive deposition of hydroxyapatite on vascular wall, but rather is an active cell-mediated process involving vascular smooth muscle cell(VSMC) transforming into osteoblast-like cells. It can be regulated by multiple factors and many signaling pathway. Recent studies indicate that Notch1 signaling pathway is significantly associated with vascular calcification. In this paper, the composition, effect and physiological function of Notch1 signaling pathway, the mechanism and regulation of vascular calcification, and the relationship between Notch1 signaling pathway and vascular calcification are summarized.