胰腺癌患者行胰十二指肠切除术后长期生存率的影响因素

目的:分析胰腺癌行胰十二指肠切除术后的长期生存率及其影响因素。方法:对1996年1月至2001年12月期间,因胰腺癌在我院行胰头癌根治性切除术66例患者进行回顾性研究,对其生存时间和临床病理特点进行比较分析。结果:66例患者5年生存率为18.3%,中位生存时间为25月。有血管浸润或淋巴结转移或肿瘤直径大于2.5cm的预后很差。结论:胰腺癌的预后很差,手术切除后长期生存率主要由肿瘤本身生物学特性决定。

Prognostic Indicators for Survival after Resection of Pancreatic Adenocarcinoma

Objective:To analyze the actual long-term outcome after the Whipple's surgery of pancreatic adenocarcinoma and to identify the characteristics shared by long-term surivors.Methods:Sixty-six patients with the disgnosis of pancreatic adenocarcinoma who received Whipple's surgery between January 1996 and December 2001 were entered into a prospective database.Their actual survival outcome and the clinicopathologic characteristics were compared retrospectively.Results:Median follow-up of survivors who had Whipple's surgery was 25 months.Actuarial 5-year survival was 18.3%.Tumors with lymph node involvement,portal vein invasion,and tumor size greater than 2.5 cm were predictors of a significantly worse survival in both univariate and multivariate analysis.Conclusion:This paper emphasizes the grim prognosis of pancreatic adenocarcinoma.Biologic characteristics remain important predictors of survival for patients with resected pancreatic cancer.