黄芪多糖对压力超负荷诱导的大鼠心肌肥大的影响

目的:探讨黄芪多糖(astragalus polysaccharides,APS)对压力超负荷所致大鼠心肌肥大的抑制作用。方法:SD大鼠随机分为5组:假手术手组、模型组、APS低剂量组(AP1)、APS高剂量组(AP2)和卡托普利组。给药8周后,分别进行心脏超声和HE染色检测心脏肥大指数及形态学改变。结果:超声检测发现,与假手术组相比,模型组左右心室质量比明显增加,舒张期左心室容量、左心室射血分数和左心室短轴缩短速率均明显降低;AP2组与模型组相比,以上指标均有显著性改善,而AP1组和模型组比较无明显差异。HE染色显示,模型组肌细胞排列疏松、肥大,AP1组和AP2组细胞排列整齐,有少量肥大细胞夹杂。结论:高剂量APS对压力超负荷大鼠的心肌肥大有明显保护作用。

Effect of Astragalus polysaccharides on cardiac hypertrophy induced by pressure overload in rat

Objective To investigate the inhibition of the astragalus polysaccharides (APS) on cardiac hypertrophy induced by pressure overload in rat. Methods 60 SD rats were randomly divided into 5 groups: Sham, Model, Captopril, low-dose APS and high-dose APS group. All these drugs were administrated for 8 weeks respectively. Echocardiography and cardiac hypertrophy index were detected respectively for the heart function, HE staining was detected to observe the cardiac morphology. Results Echocardiography showed that compared with the sham group, left and right ventricular mass ratio (LVM/RVM) of the model group significantly increased, diastolic left ventricular volume (LV Vol, d), left ventricular ejection fraction (EF) and left ventricular fractional shortening rate (FS) of the model group decreased significantly. While comparing with the model group, the indexes of the above in APS group significantly improved. HE staining showed that myocardial cells became hypertrophic and arranged loosely in model group, while the myocardial cells in AP2 group arranged in order, and the hypertrophy cells obviously decreased. But there was no significant difference between the AP1 and the model group. Conclusion APS has a high-dose group was significantly inhibited pressure overload cardiac hypertrophy in rats.