| 基质金属蛋白酶-2在胃癌组织中的表达及与腹膜扩散的关系 |
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| 引用本文： | 薛华,孙亚伟,王一波.基质金属蛋白酶-2在胃癌组织中的表达及与腹膜扩散的关系[J].实用医院临床杂志,2012,9(2):63-64. |
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| 作者姓名： | 薛华 孙亚伟 王一波 |
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| 作者单位： | 1. 四川省医学科学院·四川省人民医院细胞移植中心,四川成都610072
2. 江苏大学附属武进医院,江苏,常州,213002 |
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| 摘 要： | 目的 探讨基质金属蛋白酶-2(matrix metalloprotelnase-2,MMP-2)在胃癌组织中的表达及其与肿瘤浸润、腹膜转移之间的关系.方法 应用免疫组化S-P法检测82例胃癌组织中MMP-2的表达水平,并结合临床病理参数进行综合分析.结果 MMP-2在胃癌组织中呈高表达,与癌组织的浸润深度、淋巴结转移、临床病理分期及胃癌腹膜扩散具有相关性(P<0.05).结论 MMP-2在胃癌的表达反应了肿瘤的生物学行为,MMP-2高表达促进肿瘤转移,对胃癌的预后判定有一定意义.
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| 关 键 词： | 胃癌 基质金属蛋白酶-2 腹膜扩散 |
Expression of matrix metalloproteinase-2 and its relationship with peritoneal dissemination of gastric carcinoma |
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| XUE Hua,SUN Ya-wei,WANG Yi-bo.Expression of matrix metalloproteinase-2 and its relationship with peritoneal dissemination of gastric carcinoma[J].Practical Journal of Clinical Medicine,2012,9(2):63-64. |
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| Authors: | XUE Hua SUN Ya-wei WANG Yi-bo |
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| Institution: | 1.Department of Cell Transplantation,Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People Hospital,Chengdu 610072,China;2.Department of General Surgery,Wujin People＇s Hospital,Changzhou 213002,China) |
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| Abstract: | To investigate the expression of matrix metalloproteinase-2（MMP-2） in tissues of gastric carcinoma and its correlation with the invasion and peritoneal dissemination of gastric carcinoma. Immunohistochemistry was used to examine and analyze the expression of MMP-2 in 82 specimens of gastric carcinoma tissues. MMP-2 showed high expression in gastric carcinoma tissues.The expression of MMP-2 was closely related to the depth of invasion,lymph node metastasis,clinical stage and peritoneal dissemination of gastric carcinoma（P 0.05）. The expression of MMP-2 reflects the biological behavior of tumor.The high expression of MMP-2 can promote tumor metastasis,which has certain significance in the prognosis of gastric cancer |
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| Keywords: | Gastric carcinoma Matrix metalloproteinase-2 Peritoneal dissemination |
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