In vivo efficacy of mebendazole in containment of larval cyst mass in early stages of hydatid disease due to Echinococcus granulosus |
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| Authors: | A Wangoo N K Ganguly R C Mahajan |
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| Institution: | Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
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| Abstract: | The role of mebendazole in treatment of hydatid disease was investigated in a mouse model of human Echinococcus granulosus infection. Each animal received 2000 protoscoleces by intraperitoneal injection. Mebendazole, 50 mg/kg or 200 mg/kg body weight daily for 21 d, was given to 3 groups of animals 2, 4 and 6 months after infection. Significant decreases in numbers of cysts were seen in groups given the drug 2 and 4 months after infection, compared to the group given drug 6 months after infection. 200 mg/kg body weight was more effective in decreasing cyst numbers than 50 mg/kg. |
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