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Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: A randomized,controlled, single blind,crossover human intervention trial
Authors:Alice L. Turner  Louise V. Michaelson  Peter R. Shewry  Alison Lovegrove  Jeremy P.E. Spencer
Affiliation:1. Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK (ALT, JPES).;2. Department of Plant Sciences, Rothamsted Research, Harpenden, UK (LVM, PRS, AL).;3. School of Agriculture, Policy and Development, University of Reading, Reading, Berks, UK (PRS).;1. Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, South China Agricultural University, Guangzhou, China;2. Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, United States;3. Université Libre de Bruxelles and Nutrition Lipid Developments SPRL, Brussels, Belgium;4. Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, United States;1. School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, United Kingdom;2. National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, SO16 6YD, United Kingdom;1. Paediatric Nutrition and Human Development Research Unit, Universitat Rovira I Virgili, IISPV, C/ Sant Llorenç 21, 43201, Spain;2. Hospital Universitari Sant Joan de Reus, Av. del Dr. Josep Laporte, 2, 43204, Reus, Spain;3. Hospital Universitari de Tarragona Joan XXIII, C/Dr. Mallafré Guasch 4, 43005, Tarragona, Spain;4. Stable Isotope Laboratory, NIHR BRC Nutritional Biomarker Laboratory and Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK;5. Childhood Nutrition Research Centre, UCL Great Ormond Street Institute of Child Health, 30 Guilford St, Holborn, London, WC1N 1EH, UK;6. Unitat de Suport a la Recerca Tarragona-Reus, IDIAPJGol, Camí de Riudoms 53-55, 43204, Reus, Spain;7. Hospital Lleuger de Cambrils, Plaça de l''Ajuntament, 2-3, 43850, Cambrils, Spain;8. Serra Hunter Fellow, Spain;1. Sciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil;2. Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil;3. Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil;4. Department of Statistics, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil;5. Department of Food and Nutrition, Universidade Federal de Mato Grosso (UFMT), Cuiabá, Mato Grosso, Brazil;6. Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil;7. Department of Surgery, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil;8. Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil;1. Department of Rehabilitation, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;2. Department of Medicine, Austin Health, Melbourne Medical School, The University of Melbourne, Heidelberg, Victoria, Australia;3. Melbourne Brain Centre at Royal Melbourne Hospital, Melbourne Medical School, The Univesity of Melbourne, Parkville, Victoria, Australia;4. Department of Physiotherapy, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;5. Department of Endocrinology and Diabetes, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;6. Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Abstract:
Keywords:Bioavailability  Ferulic acid  Vascular function  High fibre bread  Human intervention  Feruloyl esterase  CVD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Cardio-Vascular Disease  FMD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Flow Mediated Dilatation  LDI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Laser Doppler Imaging  DVP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0075"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Digital Pulse Wave  BP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Blood Pressure  Ach"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  acetylcholine  3,5DHBA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0105"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  3,5-Dichloro-4-hydroxybenzoic acid
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