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Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial
Authors:Sadaf Oliai Araghi  Jessica C. Kiefte-de Jong  Suzanne C. van Dijk  Karin M.A. Swart  Kim J. Ploegmakers  M. Carola Zillikens  Natasja M. van Schoor  Lisette C.P.G.M. de Groot  Paul Lips  Bruno H. Stricker  André G. Uitterlinden  Nathalie van der Velde
Affiliation:1. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands;2. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;3. Department of Public Health and Primary Care, Leiden University Medical Center/LUMC Campus, The Hague, the Netherlands;4. Department of Geriatric Medicine, Franciscus Gasthuis & Vlietland, Schiedam, the Netherlands;5. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands;6. Amsterdam UMC, (University) of Amsterdam, Section of Geriatric Medicine, Department of Internal Medicine, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands;7. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands;8. Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands;9. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine, Endocrine Section, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands;1. Division of Endocrinology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil;2. Department of Social Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil;3. Division of Endocrinology, Faculdade de Medicina, Instituto de Ciências da Saúde,Universidade Federal do Pará, Belém, PA, Brazil;1. Division of Nephrology, Tagawa Municipal Hospital, Fukuoka, Japan;2. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;3. Fukuoka Renal Clinic, Fukuoka, Japan;4. Department of Internal Medicine, Fukuoka Dental College, Fukuoka, Japan;5. Department of Nephrology, Nara Medical University, Nara, Japan;1. Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan;2. Department of Hepato-Pancreato-Biliary Surgery, National Liver Institute, Menoufia University, Egypt;3. Department of Gastroenterological and General Surgery, St. Luke''s International Hospital, Tokyo, Japan;1. Department of Rehabilitation, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;2. Department of Medicine, Austin Health, Melbourne Medical School, The University of Melbourne, Heidelberg, Victoria, Australia;3. Melbourne Brain Centre at Royal Melbourne Hospital, Melbourne Medical School, The Univesity of Melbourne, Parkville, Victoria, Australia;4. Department of Physiotherapy, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;5. Department of Endocrinology and Diabetes, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;6. Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia;1. Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, South China Agricultural University, Guangzhou, China;2. Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, United States;3. Université Libre de Bruxelles and Nutrition Lipid Developments SPRL, Brussels, Belgium;4. Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, United States
Abstract:
Keywords:B-vitamins  Fracture  Cardiovascular disease  Long-term follow-up  B-PROOF"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0035"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  B-vitamins for the prevention of osteoporotic fractures  GPs"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  general practitioners  BMD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  bone mineral density  CVD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  cardiovascular disease  Hcy"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0075"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  homocysteine  HoloTC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  holotranscobalamin  MI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  myocardial infarction  AP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0105"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  angina pectoris  CVA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0115"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  cerebrovascular accident  TIA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0125"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  transient ischemic attack
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