老年冠心病病人血清甲状腺激素与血脂水平的检测

①目的　探讨老年冠心病病人血清中甲状腺激素水平及与血脂的关系。②方法　测定 30例正常对照者及 4 7例冠心病病人血清中总胆固醇 (TC)、三酰甘油 (TG)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)、载脂蛋白A1、载脂蛋白B、游离三碘甲状腺原氨酸 (FT3 )、游离甲状腺素 (FT4)、促甲状腺素 (TSH)水平。③结果　冠心病组FT3 、HDL、载脂蛋白A1明显低于正常对照组 (t=4 .12 4～ 5 .910 ,P <0 .0 1) ;FT4、TSH、TG、TC两组间比较无显著性差异 (t=1.4 33～ 1.85 4 ,P >0 .0 5 ) ;LDL与载脂蛋白B明显高于正常对照组 (t=3.70 5、7.6 5 0 ,P <0 .0 1)。冠心病病人FT3 、FT4与TC、TG无相关性 (r=- 0 .0 5 9～ - 0 .0 0 3,P >0 .0 5 ) ,与HDL、载脂蛋白A1呈正相关 (r =0 .32 8～ 0 .72 0 ,P<0 .0 1) ,与LDL、载脂蛋白B呈负相关 (r=- 0 .80 2～ - 0 .4 0 7,P <0 .0 5 )。④结论　冠心病病人存在FT3 下降 ,甲状腺激素水平下降可影响脂蛋白的正常代谢。

LEVELS OF THYROID HORMONE AND LIPIDS IN SERUM IN PATIENTS WITH CORONARY HEART DISEASE IN AGED

Objective\ To detect the levels of thyroid hormone in serum and its relation to blood lipid in patients with coronary heart disease(CHD) in aged.\ Methods\ Levels of total cholesterol(TC), total triglyceride(TG), high density lipoprotein(HDL), low density lipoprotein(LDL), apoA 1 and apoB in serum were measured by Beckman CX 7 automated biochemical analyzer and free triiodothyronine(FT 3), free thyroxine(FT 4) and thyroid stimulating hormone (TSH) in serum were determined by electrochemiluminescence (ECL) in 30 normal controls and 47 patients.\ Results\ The levels of FT 3, HDL and apoA 1 of the patients were lower than that of normal controls ( t=4.124-5.910, P <0.01).The differences of the levels of FT 4, TSH ,TG and TC were not significant between the two groups ( t=1.433-1.854, P >0.05). The values of LDL and apoB of the patients were higher than that of normal controls ( t=3.705,7.650, P <0.05). There was no correlation between FT 3, FT 4 and TG, TC ( r= -0.059 --0.003,P >0.05). There was a positive correlation between FT 3 and HDL as well as apoA 1 ( r=0.328-0.720,P < 0.01 ); and a negative correlation between FT 3 and LDL as well as apoB ( r=-0.802--0.407,P <0.05).\ Conclusion\ The level of FT 3 decreased in patients with CHD. The decrease of thyroid hormone may influence the normal metabolism of lipoproteins.