Leflunomide use in a cytomegalovirus infection of a patient with dermatomyositis |
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Authors: | Alberto O. Orden Juan C. Chuluyan Ana C. Colombini Rubén F. Barbera |
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Affiliation: | (1) Departments of Internal Medicine, Cl?nica San Camilo, Alfredo Bufano 2423, 1416 Buenos Aires, Argentina;(2) Departments of Infectology, Cl?nica San Camilo, Buenos Aires, Argentina |
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Abstract: | Human cytomegalovirus (CMV) is responsible for significant morbidity and mortality in immunocompromised populations, such as those suffering from dermatomyositis (DM). We present here a case study of a DM patient undergoing methotrexate treatment who presents with weakness, myalgia, elevated levels of hepatic transaminases and serological markers of CMV primo-infection. The antiviral activity of leflunomide against CMV was described recently. The use of leflunomide as an immunomodulator may have contributed to the satisfactory evolution of the treatment for a symptomatic CMV infection in an immunocompromised patient, since the typical treatment outcome is more prolonged and with additional complications. |
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