重型病毒性肝炎患者血清甲胎蛋白测定的临床意义

目的探讨重型病毒性肝炎患者血清甲胎蛋白（AFP）测定的临床意义。方法用放射免疫法测定85例重型病毒性肝炎患者血清AFP水平，并动态监测其变化。结果重型病毒性肝炎患者血清AFP异常率高达83．6％，急性重型肝炎血清AFP异常率显著低于亚急性重型肝炎及慢性重型肝炎（均P〈0．01）；重型病毒性肝炎患者血清AFP高水平组存活率显著高于AFP正常组及AFP低水平组（P〈0．01～0．05）；重型病毒性肝炎存活者血清AFP水平显著高于死亡者（P〈0．01）。结论重型病毒性肝炎患者血清AFP测定可作为判断预后的敏感指标，患者血清AFP呈高水平，说明其肝细胞再生活跃，预后相对较好。

Clinical significance of blood serum alpha-fetoprotein determination in gravis type viral hepatitis

Objective To explore the clinical significance of blood serum AFP determination in gravis type viral hepatitis. Methods The level of blood serum AFP was determined by radioimmunoassay in 85 eases of gravis type viral hepatitis, and its change was observed in a dynamic state. Results The abnormality rate of AFP was 83. 6% in the patients of gravis type viral hepatitis. The abnormality rate of AFP in acute gravis type viral hepatitis was significantly lower than that in suhacute severe hepatitis and chronic severe hepatitis(P < 0.01). The survival rate in the team with high level of AFP was significantly higher than that of teams with normal or low level of AFP(P <0.01～0.05) in the patients of gravis type viral hepatitis. The blood serum AFP level in the survivors was significant-ly higher than that of the death in the patients of gravis type viral hepatitis(P <0.01). Conclusions The blood ser-um AFP determination in gravis type viral hepatitis,can be used as a sensitive index for prognosis. A high level of AFP indicates that the hepatic cells regeneration is active and the prognosis is relatively better.