反复呼吸道感染病儿红细胞免疫功能、T细胞亚群和血清sIL－2R水平的变化

对６２例反复呼吸道感染（ＲＲＩ）病儿的红细胞免疫功能、Ｔ淋巴细胞亚群和血清可溶性白细胞胞介素－２受体（ｓＩＬ－２Ｒ）水平的变化进行了检测，并与正常对照组比较。结果表明，ＲＲＩ病儿红细胞Ｃ３ｂ受体花环率（Ｅ－Ｃ３ｂＲＲ）、红细胞免疫复合物受体花环率（Ｅ－ＩＣＲ）和红细胞Ｃ３ｂ受体花环形成促进率（ＲＦＥＲ）均明显低于对照组，而循环免疫复合物（ＣＩＣ）和红细胞Ｃ３ｂ受体花环形成抑制率（ＲＦＩＲ）明显高于对照组，差异均有极显著性（Ｐ均＜０．０１，０．００１）；ＲＲＩ病儿ＣＤ４，ＣＤ４／ＣＤ８明显降低，而ＣＤ８明显增高，与对照组比较差异有极显著性（Ｐ＜０．００１）；ＲＲＩ病儿血清ｓＩＬ－２Ｒ水平明显高于对照组（Ｐ＜０．００１）。ＲＲＩ病儿的Ｅ－Ｃ３ｂＲＲ与ＣＤ４／ＣＤ４／ＣＤ８呈正相关，而与ＣＤ８和ｓＩＬ－２Ｒ则呈负相关（ｒ＝０．５２７，０．４０９，Ｐ均＜０．００１）；ｓＩＬ－２Ｒ与ＣＤ４，ＣＤ４／ＣＤ８呈负相关，与ＣＤ８呈正相关（ｒ＝—０．５３０，—０．４９１，Ｐ＜０．００１）。提示ＲＲＩ发生与红细胞免疫功能降低、Ｔ淋巴细胞亚群异常和血清ｓＩＬ－２Ｒ水平增高有密切关系。

CHANGES IN T-LYMPHOCYTE SUBPOPULATION,SOLUBLE INTERLEUKIN-2 RECEPTOR LEVEL AND ERYTHROCYTE IMMUNE FUNCTION IN CHILDREN WITH REPEATED RESPIRATORY TRACT INFECTION

The erythrocyte immune function,the frequencies of T-lymphocyte subpopulation and soluble interleukin-2(sIL-2R) level were measured in 62 children with repeated respiratory tract infection(RRI).The results showed that the erythrocyte C3b receptor rosette rate(E-C3bRR),erythrocyte immune complex rosette rate(E-ICR) and ervthrocyte C3b receptor rosette forming effective rate(RFER) were all significantly lower in children with RRI than in the normals(P<0.001,0.01) while the serum circulatory immune complex(CIC) and erythrocyte C3b receptor rosette forming inhibitory rate(RFIR) were higher than in the normals(P<0.001,0.01).The CD4, CD4/CD8 were significantly lower and CD8 significantly higher in the children with RRI than in the normals(P<0.001).The level of sIL-2R was significantly higher in the RRI children than in the normals(P<0.001).There was a positive correlation between E-C3bRR and CD4,CD4/CD8 andanegative correlation between E-C3bRR and CD8(P<0.001 for both).The sIL-2R was negatively correlated to CD4,CD4/CD8 and positively correlated to CD8(P<0.001 for both). There results indicate that the occurrence of RRI is closely related to the decrease of erythrocyte immue function,abnormalities of T-lymphocyte subpopulation and the increase of the sIL-2R level.