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| 缺血预适应阻抑犬冠状窦血中性粒细胞CD11b/CD18的表达 | |
| 引用本文： | 谢志泉,刘伊丽,许顶立,查道刚,张远慧,陈静,郑燕列. 缺血预适应阻抑犬冠状窦血中性粒细胞CD11b/CD18的表达[J]. 基础医学与临床, 2000, 20(4): 24-26 |
| 作者姓名： | 谢志泉 刘伊丽 许顶立 查道刚 张远慧 陈静 郑燕列 |
| 作者单位： | 1. 广州军区总医院CCU科,广州,510010 2. 第一军医大学附属南方医院心内科 3. 解放军第157医院心内科,广州510515 |
| 摘 要： | 本文旨在探讨缺血预适应（ＩＰ）心肌保护效应是否与其防止中性粒细胞（ＰＭＮ）ＣＤ１１ｂ／ＣＤ１８分子的表达有关。采用犬衣降支动脉（ＬＡＤ）建立ＩＰ模型，在长缺血前各５ｍｉｎ血和再灌注，反复４次，于基础、缺血前、缺血１ｈ、再灌注０．５和２ｈ分别采集冠状窦血作式细胞仪分析ＰＭＮＣＶＤ１１ＣＤ１８的表达，并一单纯ＩＲ组比较。ＩＲ组在心肌缺因与再灌注各时点ＰＭＮＣＤ１１ｂ／ＣＤ１８表达均显著增加，而ＩＰ组除 |
| 关 键 词： | 缺血预适应 CD11b／CD18 中性粒细胞 心肌缺血 |
| 修稿时间： | 1999-01-25 |
Ischemic preconditioning attenuates the expression of neutrophils CD11b/CD18 in coronary sinus blood of dog |
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| XIE Zhi-quan,LIU Yi-li,XU Din-li,et al. Ischemic preconditioning attenuates the expression of neutrophils CD11b/CD18 in coronary sinus blood of dog[J]. Basic Medical Sciences and Clinics, 2000, 20(4): 24-26 | |
| Authors: | XIE Zhi-quan LIU Yi-li XU Din-li et al |
| Abstract: | The myocardial protection of ischemic preconditioning (IP) may be involved in its inhibition to PMNs adhesion. We therefore examined the effects of lp on the expression of CD 11b/CD18. Anesthetized open-chest dogs (n=6) subjected to 5min ischemia and 5min reperfusion for 4 times before 1 hour of left descending coronary artery (LDA) occlusion followed by 2 hours of reperfusion. Coronary sinus blood samples were obtained for flow cytometric analysis then compared with IR group at different intervals: base, pre-occlusion, 1 hour after occlusion, 30min and 2 hours after reperfusion. PMN CD 11b/CD18 expression increased significantly in IR group while no differece in IP group except for that enhanced at the time of pre-occlusion. IP attenuates ischemia-reperfusion-stimulated PMNs adhesion which may be one of the mechanism of IP protection. |
| Keywords: | ischemic preconditioning CD11b/CD18 neutrophil flow cytometer |
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