Failure of TRH and ORG 2766 hexapeptide to counteract alcoholic inebriation in man

Summary The actions and interactions of alcohol (1.5 g/kg) and two stimulant peptides were investigated in healthy volunteers. Double blind and cross over studies in 8 subjects, at one-week intervals, revealed that ORG 2766 (5 or 20 mg i.m.) and particularly TRH (10 µg/kg i.v.) enhanced rather than antagonized alcohol-induced inebriation. The interactions were associated with elevated breath alcohol concentrations. Similar studies with 8 other subjects showed that peptides given in combination with a non-alcoholic drink tended to impair performance assessed as various psychophysiological variables. However, ORG 2766 5 mg was subjectively rated as producing a feeling of improved performance.