Ovarian hyper-response to administration of an GnRH-agonist without gonadotropins |
| |
Authors: | Park Hyun Tae Bae Hyo Sook Kim Tak Kim Sun Haeng |
| |
Affiliation: | Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. |
| |
Abstract: | Several case reports have indicated that a small subgroup of patients may develop ovarian hyperstimulation following the administration of gonadotropin-releasing hormone agonists (GnRHa) without gonadotropins. However, since only few such cases have been published, it is unclear what course to follow in subsequent cycles after ovarian hyperstimulation in the first cycle using only GnRHa. A 33-yr-old woman was referred to in vitro fertilization for oocyte donation. A depot preparation (3.75 mg) of tryptorelin without gonadotropins induced ovarian multifollicular enlargement with high estradiol level, and was followed by human chorionic gonadotropin administration and oocyte retrieval. In a subsequent cycle of the same patient, a low dose of tryptorelin (0.05 mg) did not induce ovarian hyperstimulation, and resulted in clinical pregnancy. This report shows potential management of ovarian hyperstimulation following the administration of GnRHa without gonadotropins. |
| |
Keywords: | GnRH Agonist IVF Ovarian Hyperstimulation |
本文献已被 PubMed 等数据库收录! |
|