过敏性紫癜患儿血清过敏原特异性IgE的检测及意义

目的探讨反复发作性过敏性紫癜患儿血清过敏原特异性IgE的变化及与疾病发病的关系。方法采用酶联免疫吸附试验检测100例反复发作性过敏性紫癜患儿的血清过敏原特异性IgE。结果100例患儿中血清总IgE水平〉50ku／L者81例，阳性率81％，其中52例（52％）对两种以上过敏原呈阳性反应，29例（29％）对一种过敏原呈阳性反应；常见吸人性过敏原为霉菌（19／100）、尘螨（12／100）和蒿类花粉（9／100）。常见的食人性过敏原为海鱼类（28／100）、虾蟹（22／100）、牛奶（18／100）、蛋白蛋黄类（11／100）。结论反复发作性过敏性紫癜的发生与吸人性和食人性过敏原都有一定的相关性，特异性IgE检测可帮助筛选过敏原，对疾病的预防具有积极意义。

Detection of serum allergen specific IgE in the child with recurrent auergic purpura

Objective To investigate the role of allergen specific IgE in the child with recurrent auergic purpura,and to detect the relation between all kinds of allergen and the disease.Methods The serum specific IgE of allergen detected by ELISA in 100 cases of the child with recurrent auergic purpura.Results 81 cases of serum allergen-specific IgE were over than 50ku/L(81%).52 cases(52%)were positive reaction to more than two kinds of allergens and 29 cases(29%)were positive reaction to one kind of allergen.Several familiar aeroallergen mixed molds (19/100),dermatophagoides(12/100)and mugwort pollens(9/100).The most familiar food fish(28/100).shrimpand crab(22/100),milk(18/100).protein(11/100).Conclusion It suggests that aeroallergens,fish,shrimp and crab play an important role in the pathogenesis of repeating child anaphy lactic purpura.Mixed molds and protein foods are important pathogens to the disease.To detect the serum specific IgE could help screen allergens,and have important role to prevent disease.