TLR4在肠道屏障功能损伤致肝功能衰竭中的作用

Toll样受体(TLRs)存在于细胞膜上,是一类跨膜受体.TLR4是TLRs家族中识别微生物和炎性反应的主要成员.肠道屏障主要包括机械、免疫、化学和生物屏障四大部分.肝移植导致肠道缺血再灌注损伤,肠道内细菌及内毒素移位进入血循环;同时I/R损伤刺激机体释放大量内源性分子,TLR4与内毒素及内源性配体结合,促进多种细胞因子和炎性介质的释放,引起一系列炎性介质反应,甚至导致肝功能衰竭.

Role of TLR4 in liver failure caused by the damage of gut barrier

Toil-like receptors (TLRs) present in the cell membrane and are transmembrane receptors.TLR4 is a key member of the TLRs family involved in inflammatory response and recognizing microbes. Gut barrier mainly include mechanical, immunological, chemical and biological barrier four major sections. Liver transplantation leads to intestinal ischemia-reperfusion (I/R) injury, then intestinal bacteria and endotoxin translocate into the blood circulation and at the same time, I/R injury stimulates the release of a large number of endogenous molecules. TLR4 is combined with both endotoxin and endogenous ligand and promotes the release of multi-kinds of cytokines and inflammatory mediators, causing a series of inflammatory reactions,and even leading to liver failure.