| 神经干细胞移植对大鼠视神经损伤后视觉电生理的影响 |
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| 引用本文： | 刘永生,宋来君,庞长河,郝燕燕,龙江. 神经干细胞移植对大鼠视神经损伤后视觉电生理的影响[J]. 中国实用神经疾病杂志, 2005, 8(1): 33-34 |
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| 作者姓名： | 刘永生 宋来君 庞长河 郝燕燕 龙江 |
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| 作者单位： | 河南商丘市人民医院脑外科,商丘,476000;郑州大学第一附属医院,郑州,450052 |
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| 摘 要： | 目的 观察神经干细胞 (NSCs)对视神经损伤后视觉电生理变化的影响。方法 采用夹持视神经法制作大鼠视神经损伤模型 ,分别于夹伤当天和损伤后 4周一次性向视神经鞘膜内注射NSCs。植入后 4周检测夹伤视神经眼的闪光视觉诱发电位(flare visualevokedpotential,F VEP)。结果 视神经损伤后F VEP潜伏期 (wavelatency ,Wl)延长且振幅 (waveamplitude ,WA)降低 ,与正常眼比较有显著性差异 (P <0 0 1) ;NSCs移植组损伤眼F VEP与空白对照组相比有显著性差异 (P <0 0 5 ) ,延期移植组更为明显。结论 NSCs移植有效促进了视神经损伤后神经传导功能的恢复。
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| 关 键 词： | 神经干细胞 视神经损伤 闪光视觉诱发电位 |
| 文章编号： | 1672-9218(2005)01-0033-02 |
| 修稿时间： | 2004-10-31 |
Effects of transplantation of cultured embryonic stem cells on the flare-visual evoked potential of rats after optic nerve crush |
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| Liu Yongsheng ),Song Laijun ),Pang Changhe ),et al.. Effects of transplantation of cultured embryonic stem cells on the flare-visual evoked potential of rats after optic nerve crush[J]. Chinese Journal of Practical Neruous Diseases, 2005, 8(1): 33-34 |
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| Authors: | Liu Yongsheng ) Song Laijun ) Pang Changhe ) et al. |
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| Affiliation: | Liu Yongsheng 1),Song Laijun 2),Pang Changhe 2),et al.1) Department of Neurosurgery,the people's hospital of Shangqiu,Shangqiu 476000 2)The first affiliated hospital of Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Objective To study the effects of neural stem cells(NSCs) on changes of flare-visual evoked potential(F-VEP) in the crushed optic nerve rats. Methods The optic nerve injury models were induced by crushing the optic nerve 2mm retrobulbarlly.NSCs were transplanted into the crushed optic nerve, the F-VEP was observed 4 weeks after transplantation Results The F-VEP wave latency(WL) of optic nerve-crushed eyes of rats was delayed and wave amplitude(WA) was decreased, showing distinct difference from nomal F-VEP. Four weeks after NSCs transplantation, the WL and WA of F-VEP in optic nerve-crushed eyes show significant difference from the control group(P<0.05)Conclusion The transplantation of NSCs after optic nerve crush can improve the recovery of nerve impulse transition. |
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| Keywords: | Neural stem cells Optic nerve injury Flare-visual evoked potential |
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