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复方山茱萸胶囊的成型工艺研究
引用本文:李旸,杜蓉,陈鹰,许明旺. 复方山茱萸胶囊的成型工艺研究[J]. 中国药师, 2012, 15(6): 813-815
作者姓名:李旸  杜蓉  陈鹰  许明旺
作者单位:1. 广州军区武汉总医院,武汉,430070
2. 华中科技大学同济医学院附属梨园医院
摘    要:目的:确定复方山茱萸胶囊的最佳成型工艺.方法:通过对不同辅料对流动性,吸湿性,成型性的考察筛选制备颗粒的辅料,优选最佳制粒成型工艺,并测定临界相对湿度.结果:最佳成型工艺为浸膏粉∶微晶纤维素∶磷酸氢钙=1:0.12:0.03,生产环境的相对湿度宜控制在62%以下.结论:本试验确定的成型工艺能为其实际大生产提供依据.

关 键 词:复方山茱萸胶囊  成型工艺  临界相对湿度
收稿时间:2011-12-30
修稿时间:2012-02-28

Study on Forming Process of Compound Cornus Capsules
Li Yang,Du Rong,Chen Ying and Xu Mingwang. Study on Forming Process of Compound Cornus Capsules[J]. China Pharmacist, 2012, 15(6): 813-815
Authors:Li Yang  Du Rong  Chen Ying  Xu Mingwang
Affiliation:1.Wuhan General Hospital of Guangzhou Military Region,Wuhan 430070,China;2.Liyuan Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology)
Abstract:Objective: To determine the best forming process of compound cornus capsules.Method: The effects of different excipients on the fluidity,wettability and formability of the powder were investigated to select appropriate materials and promising preparation process.The critical relative humidity was also measured in the preparation process.Result: The optimal ratio of extract powder,microcystalline cellulose(MCC) and calcium hydrogen phosphate was 1∶ 0.12∶ 0.03.The relative humidity of the production and storage environment was below 62%.Conclusion: The research can provide the suggestion for the mass preparation of compound cornus capsules.
Keywords:Compound cornus capsules   Forming process   Critical relative humidity
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