硫酸镁联合甲砜霉素治疗泛发性脓疱型银屑病的临床疗效观察

目的　观察硫酸镁联合甲砜霉素治疗泛发性脓疱型银屑病的临床疗效。方法　每日 2 5%硫酸镁注射液10～ 2 0ml(小儿酌情减量 )静滴 ,同时辅以甲砜霉素 0 .75g口服 [小儿剂量为 2 5～ 50mg/ (kg .d) ] ,治疗泛发性脓疱型银屑病 12例 ,15天为 1疗程 ,1疗程后观察疗效、起效时间和不良反应。结果　 10例临床治愈 ,2例显效 ,全部在 3天内起效 ;不良反应轻 ,停药后消失。结论　硫酸镁联合甲砜霉素治疗泛发性脓疱型银屑病疗效显著 ,副作用少 ,是治疗银屑病的良好药物。

Clinical Observation of Magnesium Sulphate United with Thiamphenicol on Treating Zumbusch Pattern Psoriasis Pustulosa

ObjectiveTo observe the clinical effect of ma gnesium sulphate united with thiamphenicol on treating Zumbusch pattern psoriasi s pustulosa (generalized psoriasis pustulosa).MethodsTwelve patients were drop-fed with magnesium sul phate with the dosage of 2.5-5 g per day (the dosage of children should be cut down).At the same time,they took thiamphenicol with the dosage of 0.75g everyda y(the dosage of children was 25-50 mg per kilogram everyday). Fifteen days later ,we wrote down the effect of the treatment,the date when the drug took effect an d the adverse reactions.ResultsTen patients were cured clinically.Two patients a chieved obvious effects.The drug took effect within three days.The advese reacti ons were slight and could disappear if patients stopped taking the drug.ConclusionMagnesium sulphate united with thiamphenicol h ad obvious effect on Zumbusch pattern psoriasis pustulosa with few side-effects .