针刺对肥胖大鼠胆囊收缩素的影响

目的　探讨针刺对中枢和外周肥胖大鼠胆囊收缩素 (CCK)、瘦素和胰岛素 (INS)含量的影响。方法　观察针刺治疗前后肥胖大鼠体重、Lee′s指数、体脂以及中枢和外周CCK、瘦素和INS含量的变化。结果　肥胖大鼠体重、Lee′s指数、体脂以及血清瘦素和INS显著高于正常大鼠水平 ,而大脑皮质、孤束核和血清CCK以及下丘脑瘦素和INS含量均显著低于正常大鼠水平。相关分析显示 ,肥胖指标与中枢和外周的CCK水平呈负相关。针刺治疗取得良好减肥疗效的同时 ,肥胖大鼠血清瘦素和INS水平明显回降 ,而大脑皮质、孤束核和血清CCK以及下丘脑瘦素和INS水平均呈明显回升。结论　大脑皮质、孤束核和血清CCK水平异常低下以及瘦素和INS血脑转运异常可能是产生肥胖的重要因素。针刺对中枢和外周的CCK、瘦素和INS水平的良性调整作用可能是针刺减肥的重要作用机制之一。

Effect of acupuncture on cholecystokinin of obese rats

Objective To explore the effect of acupuncture on the contents of central and peripheral cholecystokinin (CCK),leptin and insulin (INS) in obese organism.Methods The changes of body weight,Lee′s index,body fat,as well as the contents of central and peripheral CCK,leptin and INS in obese rats were observed before and after acupuncture.Results The body weight,Lee′s index,body fat,and the levels of serum leptin and INS in obese rats were all markedly higher than those in the normal rats, but the CCK levels of cerebral cortex,nuclei tractus solitarii and serum,as well as the levels of hypothalamic leptin and INS in obese rats were all lower than those in normal rats.There was negative correlation between the obesity index and levels of central and peripheral CCK.After acupuncture treatment the marked weight loss was achieved while the levels of serum leptin and INS obviously decreased,the CCK levels of cerebral cortex, nuclei tractus solitarii and serum as well as the levels of hypothalamic leptin and INS obviously increased in obese rats.Conclusion The abnormal decrease in CCK levels of cerebral cortex,nuclei tractus solitarii and serum as well as the abnormal transport of blood brain barrier of leptin and INS may be an important cause for the obesity.The good regulation of acupuncture on the levels of central and peripheral CCK,leptin and INS is possibly the very important mechanism of acupuncture slimming.