Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima |
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| Authors: | Promsawan Netnapa Kittakoop Prasat Boonphong Surat Nongkunsarn Pakawan |
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| Institution: | Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand. |
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| Abstract: | Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6 beta-benzoyl-7 beta-hydroxyvouacapen-5 alpha-ol (1) and 6 beta-cinnamoyl-7beta-hydroxyvouacapen-5 alpha-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory concentration (MIC) of 6.25 microg/mL, whereas the benzoyl analogue (1) was less active (MIC 25 microg/mL). Both compounds expressed moderate cytotoxic activity towards KB (human oral carcinonoid cancer), BC (human breast cancer) and NCl-H187 (small cell lung cancer) cell lines. |
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