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| 二十五味珍珠丸对实验性脑缺血大鼠脑毛细血管通透性及脑含水量的影响 | |
| 引用本文： | 张黎明,刘生,马骏,吴国泰,任远. 二十五味珍珠丸对实验性脑缺血大鼠脑毛细血管通透性及脑含水量的影响[J]. 中国药房, 2006, 17(9): 664-666 |
| 作者姓名： | 张黎明 刘生 马骏 吴国泰 任远 |
| 作者单位： | 1. 甘肃省天水市第一人民医院药剂科,天水市,741000 2. 甘肃省医药职工中专学校,兰州市,730000 3. 甘肃中医学院,兰州市,730000 |
| 摘 要： | 目的:研究二十五味珍珠丸对大鼠脑缺血所致脑水肿的影响。方法:建立以颈总动脉结扎致大鼠不完全性脑缺血模型,通过伊文氏蓝法和重量法观察二十五味珍珠丸对脑毛细血管通透性、脑指数、脑含水量的影响。结果:二十五味珍珠丸预防给药可明显降低模型大鼠脑毛细血管通透性、脑含水量和脑指数,减轻脑水肿(P<0.05)。结论:二十五味珍珠丸对实验性大鼠脑缺血所致脑水肿有一定的预防作用。 |
| 关 键 词： | 二十五味珍珠丸 脑缺血 大鼠 脑水肿 预防作用 |
| 文章编号： | 1001-0408(2006)09-0664-03 |
| 收稿时间： | 2006-01-06 |
| 修稿时间： | 2006-03-17 |
Effects of Ershiwuwei Zhenzhu Wan on Cerebral Capillary Permeability and Cerebral Water Content in the Experimental Rats with Cerebral Ischemia |
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| ZHANG Liming,LIU Sheng,MA Jun,WU Guotai,REN Yuan. Effects of Ershiwuwei Zhenzhu Wan on Cerebral Capillary Permeability and Cerebral Water Content in the Experimental Rats with Cerebral Ischemia[J]. China Pharmacy, 2006, 17(9): 664-666 | |
| Authors: | ZHANG Liming LIU Sheng MA Jun WU Guotai REN Yuan |
| Affiliation: | 1.Dept. of Pharmacy, The First Hospital of Tianshui City in Gansu Province, Tianshui 741000, China; 2.Gansu Provincial Medicine Vocational School, Lanzhou 730000,China; 3.Gansu TCM College, Lanzhou 730000,China |
| Abstract: | OBJECTIVE:To study the effects of Ershiwuwei zhenzhu wan(ZZW)on cerebral edema induced by cerebral ischemia of rats.METHODS:The incomplete cerebral ischemia model was induced by occlusion of arteria carotis in rats,the effects of ZZW on cerebral capillary permeability,cerebral index and cerebral water content were observed by azo-blue method and weighting method.RESULTS:Preventive medication of ZZW could significantly decrease cerebral capillary per-meability,cerebral index and cerebral water content and palliate cerebral edema(P<0.05).CONCLUSION:ZZW is proved to be of preventive effect on cerebral edema induced by cerebral ischemia of experimental rats. |
| Keywords: | Ershiwuwei zhenzhu wan Cerebral ischemia Rats Cerebral edema Preventive effect |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |