IgG anti-ganglioside antibodies and their subclass distribution in two patients with acute and chronic motor neuropathy. |
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Authors: | C Garcia Guijo A Garcia-Merino G Rubio A Guerrero A Cruz Martinez J Arpa |
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Institution: | Department of Neurology, Hospital La Paz, Madrid, Spain. |
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Abstract: | IgG anti-ganglioside antibodies were found in two patients with motor neuropathy. The first patient had a chronic axonal neuropathy with persistently elevated anti-GM1 antibodies. The second patient had an acute axonal neuropathy with anti-GM1, GD1b and asialoGM1 antibodies. In both, the IgG subclass study showed that the antibodies belonged to the IgG1 subclass. An enzyme-linked immunosorbent assay (ELISA) for light chains revealed anti-ganglioside antibodies of the lambda type. |
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