| 酪酪肽对人胰腺癌细胞生长的调节作用及其机制研究 |
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| 引用本文： | 傅强,王梅,王雅杰,张贤康,张忠兵. 酪酪肽对人胰腺癌细胞生长的调节作用及其机制研究[J]. 胃肠病学, 2002, 7(1): 18-20,26 |
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| 作者姓名： | 傅强 王梅 王雅杰 张贤康 张忠兵 |
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| 作者单位： | 1. 第二军医大学长海医院肿瘤科,200433
2. 第二军医大学附属长征医院消化内科 |
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| 摘 要： | 目的：观察酪酪肽（PYY）对人胰腺癌细胞生长的抑制作用及其对细胞内环磷酸腺苷(cAMP)含量的影响。方法：采用^3H-胸腺嘧啶（^3H-TdR）掺入、放射免疫法，测定PYY对人胰腺癌细胞株SW－1990生长的调节作用及其对细胞内cAMP含量的影响。结果：PYY对SW－1990细胞的生长有显著抑制作用，随其浓度的增加或作用时间的延长而增强，并可减少细胞内cAMP的产生呈剂量依赖关系。结论:PYY树人胰腺癌细胞生长有抑制作用，其机制可能与通过降低细胞内cAMP含量有关。
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| 关 键 词： | 胰腺肿瘤 环AMP 酪酪肽 细胞生长 抑制作用 |
Inhibitory Effect of PYY on Pancreatic Carcinoma Cells and its Mechanisms |
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| FU Qiang,WANG Mei,WANG Yajie,ZHANG Xiankang,ZHANG Zhongbing. Inhibitory Effect of PYY on Pancreatic Carcinoma Cells and its Mechanisms[J]. Chinese Journal of Gastroenterology, 2002, 7(1): 18-20,26 |
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| Authors: | FU Qiang WANG Mei WANG Yajie ZHANG Xiankang ZHANG Zhongbing |
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| Abstract: | Background/Aims: To investigate the inhibitory effect of PYY on pancreatic carcinoma cell line SW-1990 and its relationship between the concentrations of intracellular cAMP and expression of mutated p58 protein. Methods: The growth of SW-1990 cells and the concentrations of intracellular cAMP were detected by 3H-TdR incorporation assay, and immunoradiation assay, respectively. Results: A significant inhibitory effect of PYY on SW-1990 was observed and the effect was augmented when the concentrations of PYY increased or duration of action was prolonged. The decrease of concentra- tions of intracellular cAMP was dose-dependent. Conclusions: PYY can inhibit the growth of pancrea- tic carcinoma cells by reducing the expression of intracellular cAMP. |
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| Keywords: | Pancreatic Neoplasms Cyclic AMP Peptide YY |
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