套细胞淋巴瘤治疗进展

 套细胞淋巴瘤是一种难以治愈的非霍奇金淋巴瘤亚型。对加用利妥昔单抗高剂量化疗、放射免疫治疗、自体干细胞移植、异基因干细胞移植以及靶向治疗进展进行了综述。常规化疗疗效差，加用利妥昔单抗联合化疗方案大剂量治疗能够提高疗效，放射免疫治疗有一定潜力。自体干细胞移植能够改善生存，复发患者可以考虑行非清髓异基因移植。多种靶向治疗进入临床试验，具有一定疗效。

Advance on treatment of mantle cell lymphoma

Mantle cell lymphoma is an incurable subtype of non-Hodgkin lymphoma. This review focuses on its treatment progress, including high-dose chemotherapy combining rituximab, radioimmunotberapy, autologous stem cell transplatation, allogenetic stem cell transplatation and targeting therapy. Comparing from the disappointed result of regular chemotherapy, adding rituximab or high-dose regimen could improve the effect. And the radioimmunotherapy has also got some potential results. Autologous stem cell transplantation could increase the survival rate, but non-myeloablative allogenetic stem cell transplantation should be considered on relapsed patients. Till now diverse targeted medicine came into clinical trials and some of them seems competent in mantle cell lymphoma.