吡喹酮水凝胶栓剂的制备及含量测定

目的:制备吡喹酮水凝胶栓剂,并建立其含量测定方法。方法:以正交试验法筛选基质最佳处方,采用紫外分光光度法测定主药吡喹酮的含量。结果:最佳基质处方为泊洛沙姆P407/P188(15%∶20%)、海藻酸钠0.6%、乙醇15%,由此制得的吡喹酮水凝胶栓剂在体温下胶凝,粘度适中;吡喹酮检测浓度在0.2~1.0mg/ml范围内线性关系良好(r=0.9 999),平均加样回收率为(102.44±0.69)%。结论:该处方设计合理,制备工艺可靠,含量测定方法简便、快速、准确。

Preparation and Content Determination of Praziquantel Aquogel Suppository

OBJECTIVE:To prepare praziquantel aquogel suppositories and to establish its assay method.METHOD:The optimal formula of the base was optimized by orthogonal experiment and the content of principal agent-praziquantel was determined by UV spectrophotometry.RESULTS:The optimized formula of the base was as follows,poloxamer P407∶P188(15%∶20%),sodium alginate 0.6%and ethyl alcohol 15%,the praziquantel aquogel suppositories prepared in this formula could be jellified under the body temperature with optimal viscosity.Good linear relationship occurred when the detection concentration of praziquantel was within a range of 0.2～10mg/ml(r=0.9 999),the average recovery of which was(102.44±0.69)%.CONCLUSION:The design of the formula is reasonable;the preparation process is reliable and the method for assaying is simple,fast and accurate.