| 黄芪多糖对小鼠腹腔巨噬细胞免疫功能的调节作用研究 |
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| 引用本文： | 姚金凤,王志新,张晓勇,张瑞峰. 黄芪多糖对小鼠腹腔巨噬细胞免疫功能的调节作用研究[J]. 河南大学学报(医学版), 2005, 24(1): 34-36 |
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| 作者姓名： | 姚金凤 王志新 张晓勇 张瑞峰 |
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| 作者单位： | 郑州大学,药学院,河南,郑州,450052;河南大学,医学院,河南,开封,475001;南阳医专,附属医院,河南,南阳,473000;郑州大学,第一附属医院,河南,郑州,450052 |
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| 摘 要： | 目的:研究黄芪多糖(APS)增强巨噬细胞的免疫作用,探讨其调节机体免疫功能的机理。方法:在体外培养的小鼠腹腔巨噬细胞中加入不同浓度的APS后,观察其对巨噬细胞一氧化氮(NO)合成及对肿瘤细胞杀伤活性的影响。结果:APS能促进巨噬细胞NO合成,并能显著增强小鼠腹腔巨噬细胞对黑色素瘤细胞的杀伤作用。结论:APS能增强小鼠腹腔巨噬细胞的免疫作用,可能是其抗肿瘤作用的机理之一。
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| 关 键 词： | 黄芪多糖 巨噬细胞 免疫调节 |
| 文章编号： | 1672-7606(2005)01-0034-03 |
| 修稿时间： | 2004-12-10 |
Study on immunomodulatory effect of Astragalus Polysaccharide on mice peritoneal macrophage |
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| YAO Jin-feng,WANG Zhi-xin,ZHANG Xiao-yong,ZHANG Rui-feng. Study on immunomodulatory effect of Astragalus Polysaccharide on mice peritoneal macrophage[J]. Journal of Henan University, 2005, 24(1): 34-36 |
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| Authors: | YAO Jin-feng WANG Zhi-xin ZHANG Xiao-yong ZHANG Rui-feng |
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| Affiliation: | YAO Jin-feng 1,WANG Zhi-xin 2,ZHANG Xiao-yong 3,ZHANG Rui-feng 4 |
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| Abstract: | Objective: To investigate the immunomodulatory effect of Astragalus Polysaccharide on macrophage and explore the mechanism of its immunomodulatory.Methods: By adding different concentration of APS into cultured mice peritoneal macrophage in vitro, the influence of APS on the synthesis of nitro oxide (NO) was observed. The microculture tetrazoli-um (MTT) assay was used to determine the cytotoxicity of macrophage induced by APS.Results: APS could significantly increase NO synthesis and enhance the effects of mice peritoneal macrophage on killing carcinoma cells. Conclusion: APS can enhance the immune function of macrophage, which is one of the mechanism of anticancer. |
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| Keywords: | Astragalus Polysaccharide macrophage immune regulation |
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