| 介质和释放度测定方法对不同类型骨架片释药的影响 |
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| 引用本文： | 林晓,修彦凤,陈济民. 介质和释放度测定方法对不同类型骨架片释药的影响[J]. 中国医药工业杂志, 2004, 35(1): 22-24 |
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| 作者姓名： | 林晓 修彦凤 陈济民 |
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| 作者单位： | 1. 上海中医药大学中药学院药剂教研室,上海,201203
2. 沈阳药科大学药学院,辽宁沈阳,110016 |
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| 摘 要： | 分别以不同的释放介质或释放度测定方法测定了模型药物盐酸氢吗啡酮在羟丙甲纤维素(HPMC)骨架片、十八醇骨架片、乙基纤维素骨架片和HPMC-十八醇混合骨架片中的释放行为.结果表明,释放介质的离子强度对含HPMC的骨架片的释药有影响;采用不同的测定方法对含十八醇或HPMC的骨架片有显著差异.
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| 关 键 词： | 盐酸氢吗啡酮 骨架片 羟丙甲纤维素 十八醇 乙基纤维素 |
| 文章编号： | 1001-8255(2004)01-0022-03 |
Effects of release media and test methods on drug release from different types of matrices |
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| LIN Xiao,XIU Yan-Feng,CHEN Ji-Min. Effects of release media and test methods on drug release from different types of matrices[J]. , 2004, 35(1): 22-24 |
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| Authors: | LIN Xiao XIU Yan-Feng CHEN Ji-Min |
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| Abstract: | The release behaviors of model drug hydromorphone hydrochloride from HPMC matrix, octadecanol matrix, EC matrix or HPMC-octadecanol combined matrix were determined using different release media or drug release test methods. The results showed that ionic strength of release medium could affect drug release from matrices containing HPMC and the release from matrices containing octadecanol or HPMC could be significantly different when determined by different test methods. |
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| Keywords: | hydromorphone hydrochloride matrices HPMC octadecanol EC |
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