| 二甲双胍联合降脂、生活方式干预对非酒精性脂肪性肝病的治疗作用 |
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| 引用本文： | 陈少龙,何秀芬. 二甲双胍联合降脂、生活方式干预对非酒精性脂肪性肝病的治疗作用[J]. 中国实用医药, 2010, 5(15): 13-14 |
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| 作者姓名： | 陈少龙 何秀芬 |
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| 作者单位： | 1. 广东省揭阳市红十字会慈云医院内科,520031
2. 广东省揭阳市红十字会慈云医院功能科彩超室,520031 |
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| 摘 要： | 目的观察二甲双胍联合降脂、生活方式干预治疗对非酒精性脂肪性肝病患者治疗效果。方法对2007年8月至2009年10月在广东省揭阳市红十字会慈云医院门诊确诊100例NAFLD患者。随机分治疗组和对照组各50例,治疗组给予二甲双胍、降脂、运动、饮食控制。对照组应用运动、生活方式干预,治疗观察6个月。比较两组治疗前后肝酶学、肝脏超声、体质量指数、血脂、血糖、胰岛素以及HOMA胰岛素抵抗指标变化。结果治疗组有效率为90%,对照组有效率为56%,两组差异有统计学意义（P〈0.05）。肝酶学、肝脏超声、体质量指数、血脂、血糖、胰岛素以及HOMA胰岛素抵抗指标改善情况治疗组优于对照组（P〈0.05）。结论对NAFLD患者在进行饮食、运动治疗同时予以二甲双胍、降脂药治疗,改善NAFLD症状及肝酶学及胰岛素抵抗疗效优于单纯的节食减重治疗。
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| 关 键 词： | 非酒精性脂肪性肝病 降脂药 胰岛素抵抗 二甲双胍 |
The efficacy of combined therapeutic life style change with metformin and lipid-lowering drug therapy in nonalcoholic fatty liver disease |
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| CHEN Shao-long,HE Xiu-fen. The efficacy of combined therapeutic life style change with metformin and lipid-lowering drug therapy in nonalcoholic fatty liver disease[J]. China Practical Medical, 2010, 5(15): 13-14 |
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| Authors: | CHEN Shao-long HE Xiu-fen |
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| Affiliation: | CHEN Shao-long,HE Xiu-fen.Department of Medicine,The Redcross Ciyun Hospital Jieyang,520031,China |
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| Abstract: | Objective To oberserve the effect of life style change with metformin and lipid-lowering drug in treatment nonalcoholic fatty liver disease (NAFLD) .Methods One-hundred cases of NAHLD were divided into two groups,and each group had fifty cases.The control group was offered therapeutic life style change advice,treatement group was given metformin and lipid-lowering drug on the basis of control group for six months.The changes of liver enzyme tests,ultrasonic examination,body mass index,lipid profiles,plasma ... |
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| Keywords: | Nonalcoholic fatty liver disease Lipid-lowering drug Insulin resistance Metformin |
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