双相I型障碍躁狂发作患者高尿酸血症发生率及其影响因素的研究

目的：探讨双相 I 型躁狂发作患者高尿酸血症（HUA）的发生率及其影响因素。方法：检测77例双相 I 型躁狂发作住院患者（患者组）和77名健康对照者（正常对照组）血清尿酸水平，同时检测体质量、腰臀比、血压及三酰甘油（TG）水平。结果：患者组 HUA 的发生率28.6%（22例）显著高于正常对照组7.8%（6例）（χ2=11.18，P <0.01）。平均血清尿酸水平患者组（365.19±103.45）μmol/ L显著高于正常对照组（301.77±76.04）μmol/ L，差异有统计学意义（F =25.70，P <0.01）；男性血清尿酸水平高于女性（381.43±99.02）vs（291.38±70.33）]μmol/ L（F =50.08，P <0.01）。相关分析显示，患者组中性别与血清尿酸水平呈负相关（r =-0.56，P <0.01）；TG 水平与血清尿酸水平呈正相关（r =0.419，P <0.01）。结论：双相 I 型障碍躁狂发作患者 HUA 发生率增加并与性别、血清 TG 水平相关。

Study on the Prevalence and relative factors of hyPeruricemia in the Patients with manic ePisodes of bi-Polar I disorder

Objective:To explore the prevalence and relative factors of hyperuricemia(HUA)in the pa-tients with manic episodes of bipolar I disorder. Method:Seventy-seven inpatients with manic episodes of bi-polar disorder(patient group)and 77 healthy individuals(normal control group)were enrolled. Serum levels of uric acid,body mass index,waist-hip ratio,blood pressure and three acylglycerin level(TG)were measured. Results:The prevalence rate of HUA was 28. 6%(22 cases)in the patient group and 7. 8%(6 cases)in the normal control group. It was significantly higher in patient group than normal control group(χ2 = 11. 18,P <0. 01). The average serum uric acid level of patient group(365. 19 ± 103. 45)μmol/ L was significantly higher than that of normal control group(301. 77 ± 76. 04)μmol/ L,the difference was statistically significant(F =25. 70,P < 0. 01). The level of serum uric acid was higher in men than in women(381. 43 ± 99. 02)vs (291. 38 ± 70. 33)μmol/ L,(F = 50. 08,P < 0. 01)]. Correlation analysis showed gender had negatively corre-lation(r = - 0. 56,P < 0. 01)and TG had positive correlation(r = 0. 419,P < 0. 01)with serum levels of uric acid. Conclusion:The prevalence of hyperuricemia in the patients with manic episodes of bipolar I disorder increased,which was associated with gender TG.