慢性精神分裂症患者认知功能与血清C-反应蛋白的关联研究

目的:探讨慢性精神分裂症患者血清C-反应蛋白(CRP)水平与神经认知功能的相关性。方法:检测50例符合《美国精神障碍诊断与统计手册》第4版精神分裂症诊断标准的女性患者(患者组)和50名健康志愿者(正常对照组)血清CRP水平;采用阳性与阴性症状量表(PANSS)评估患者的临床症状,威斯康星卡片分类测试(WCST)、连线测试(TMT)评估患者的认知功能;对CRP水平与临床症状及认知功能进行相关分析并与正常对照组进行比较。结果:患者组血清CRP水平明显高于正常对照组(t=9.203,P0.001);WCST、TMT测验成绩明显差于正常对照组(t=4.462~6.815,P均0.001)。患者组血清CRP水平与PANSS总分及阴性症状分呈正相关(r=0.422,r=0.372;P0.05);与WCST正确数、完成分类数呈负相关(r=-0.364,r=-0.375;P0.05),与WCST错误总数、持续错误数、随机错误数呈正相关(r=0.341,r=0.346,r=0.381;P均0.05);与TMT-A、TMT-B呈正相关(r=0.411,r=0.483;P均0.05)。结论:慢性期精神分裂症患者存在明显免疫异常,血清CRP水平与认知功能和阴性症状密切相关。

Study of the correlation between cognitive function and serum C-reactive Protein(CRP)in chronic schizoPhrenia

Objective:To explore the relationship of serum C-reactive protein(CRP)and cognitive func-tion in chronic schizophrenia. Method:Fifty female patients meeting the criteria of DSM-IV for schizophrenia and 50 healthy volunteers were recruited. The serum CRP was determined. The clinical symptoms were assessed by positive and negative symptoms scale(PANSS),Wisconsin card sorting test(WCST),attachment test(TMT) were administered to evaluate cognitive function. Results:The serum CRP levels in schizophrenia group were significantly higher than those in control group(t = 9. 203,P < 0. 001). The scores of WCST and TMT in schizo-phrenia group were significantly worse than those in control group(t = 4. 462 ~ 6. 815,P < 0. 001). The serum CRP levels in schizophrenia group and PANSS total scores and negative symptoms were positively correlated (r = 0. 422,0. 372;P < 0. 05);and WCST number correctly,complete the classification number showed a nega-tive correlation(r = - 0. 364,- 0. 375;P < 0. 05),and total number of errors in the WCST,sustained error, random error was positively related(r = 0. 341,0. 346,0. 381;P < 0. 05);TMT-A and TMT-B was positively re-lated(r = 0. 411,0. 483;P < 0. 05). Conclusion:There is obvious immune abnormality in chronic schizo-phrenia. The serum CRP is associated with cognitive fuction and negative symptom.