他克莫司与雷公藤多甙联合治疗口腔扁平苔藓的临床研究

目的：评价他克莫司与雷公藤多甙联合治疗口腔扁平苔藓（ OLP）的疗效。方法：将纳入研究的89例单纯型OLP患者随机分为3组，分别采用“局部涂抹0．1％他克莫司软膏＋口服雷公藤多甙片”、单纯涂抹0．1％他克莫司软膏、单纯口服雷公藤多甙片的方法治疗4周，在治疗结束时和治疗结束半年后分别进行复查，比较各组疗效。结果：联合应用0．1％他克莫司软膏与雷公藤多甙片治疗OLP显示出满意的短期与长期疗效，统计学差异显著，且不良反应轻微。结论：他克莫司与雷公藤多甙联合治疗口腔扁平苔癣疗效满意。

A clinical study of tacrolimus plus tripterygium glocosides in treatment of patients with oral lichen planus

Objective:To evaluate curative effects of Tacrolimus combining with tripterygium glocosides on oral li?chen planus through a clinical test. Method:Eighty?nine patients suffering from simplex oral lichen planus were divided into 3 groups at random. The patients of every group were treated for 4 weeks by local inunction of 0. 1% Tacrolimus ointment combining with oral drug of tripterygium glocosides,or local inunction of 0. 1% Tacrolimus ointment solely,or oral drug of tripterygium glocosides solely,respectively;each patient was re?examined both at the end of therapy and half a year later,thus the curative effects of each group were compared with one another. Result:Local inunction of 0. 1% Tacrolimus ointment combining with oral drug of tripterygium glocosides showed satisfactory curative effect both in short term and long time,which had statistically significant differences,and the adverse reactions were mild. Conclusion:The results indicate that Tacrolimus combining with tripterygium glocosides has a satisfactory curative effect on oral lichen planus,this approach is worthy of clini?cal promotion and application.