| IL18R1基因多态性与中国汉族精神分裂症的关联性分析 |
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| 引用本文： | 孙莉,程灶火,张付全,徐勇. IL18R1基因多态性与中国汉族精神分裂症的关联性分析[J]. 临床精神医学杂志, 2016, 0(2): 109-111 |
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| 作者姓名： | 孙莉 程灶火 张付全 徐勇 |
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| 作者单位： | 1. 214000,南京医科大学附属无锡精神卫生中心;2. 山西医科大学第一附属医院 |
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| 摘 要： | 目的:探讨IL18受体IL18R1基因多态性与中国汉族精神分裂症的关系。方法:采用病例对照研究方法,选取1 174例精神分裂症患者(病例组)与1 120名正常健康对照者(对照组),利用连接酶检测-聚合酶链反应(LDR-PCR)方法对IL18R1基因多态位点rs1035130进行基因分型,观察其等位基因及基因型与精神分裂症发病风险的关系。结果:rs1035130的基因型与等位基因频率在病例组与正常对照组中的分布差异无统计学意义(P0.05)。结论:IL18R1基因rs1035130多态性可能与中国汉族精神分裂症无关。
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| 关 键 词： | IL18R1 基因 精神分裂症 多态性 |
Association of IL18R1 gene rs1O3513O PolymorPhism with schizoPhrenia |
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| Abstract: | ObJective:To explore the association between IL18R1( IL18receptor1)polymorphism and schizophrenia. Method:rs1035130 was genotyped by LDR-PCR methods,and the association of its polymor-phism and schizophrenia risk was analyzed in a case-control study with 1174 schizophrenic patients and 1120 healthy controls. Results:No significant differences for genotype and allete gene in IL18R1 gene were presen-ted between schizophrenic patients and healthy controls(P ﹥ 0. 05). Conclusion:IL18R1 gene rs1035130 may not relate to schizophrenia in Chinese Han population. |
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| Keywords: | IL18R1 schizophrenia polymorphism |
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