围绝经期妇女罹患抑郁症的危险因素分析

目的:探讨围绝经期妇女抑郁症的危险因素。方法:80例确诊为抑郁症的围绝经期女性患者(抑郁症组)和120例非抑郁症的围绝经期女性患者(对照组)进行艾森克人格量表(EPQ)、生活事件量表(LES)、社会支持量表(SSRS)的自评,同时检测两组血雌二醇激素(E2)及促卵泡刺激素(FSH)水平并进行比较。结果:抑郁症组血E2水平(t=-8.17,P=0.000)及SSRS主观支持得分(t=-3.44,P=0.001)低于对照组;血FSH水平(t=13.45,P=0.000)、LES总事件刺激分(t=5.42,P=0.00)、负性事件刺激分(t=7.97,P=0.000)、EPQ-N(神经质)分(t=8.32,P=0.000)、EPQ-P(精神质)分(t=3.84,P=0.00)高于对照组。多因素非条件Logistic回归提示,血E2、FSH水平、LES负性事件评分、EPQ-N评分的回归系数β分别为-0.117、1.116、0.372、0.290(P0.01或P0.001)。结论:血E2、FSH水平、社会心理因素、负性事件刺激及神经质人格是围绝经期妇女罹患抑郁症的危险因素。

Risk factors study of perimenopausal depression

Objective:To explore the risk factors of perimenopausal depression. Method:The study group(80 cases)with perimenopausal depreesion and the control group(120 cases)without perimenopausal depression subjects received peripheral blood tests including estradiol(E2)and follicle-stimulating hormone (FSH). Eysenck personality infentory( EPQ),life event scale( LES)and social support revalued scale (SSRS)were administered to all subjects. Results:The study group showed lower concentration of E2(t =- 8. 17,P = 0. 000)and SSRS(t = - 3. 44,P = 0. 001)than the control group,while the study group showed higher FSH(t = 13. 45,P = 0. 000),LES total score( t = 5. 42,P = 0. 00 ),LES negative event score (t = 7. 97,P = 0. 000),EPQ neurotic score ( t = 8. 32,P = 0. 000 ) and EPQ psychotic score (t = 3. 84,P = 0. 00). Logistic regression analysis showed the coefficient β of estradiol,E2 level,blood FSH lev-el,negative event(LES)and nervousness(EPQ)were - 0. 117,1. 116,0. 372,0. 290 respectively( P < 0. 01 or P < 0. 001). Conclusion:The risk factors of perimenopausal depression are the negative life event,nervous personality,lower concentration of estradiol and higher concentration offollicle-stimulating hormone.