BXSB小鼠外周B淋巴细胞异常增生的研究

系统性红斑狼疮（ＳＬＥ）突出的免疫学异常表现是Ｂ淋巴细胞的异常增生与活化，其发生机制至今不明，本文以遗传性自发性ＳＬＥ模型ＢＸＳＢ小鼠为对象，采用体内ＢｒｄＵ标记法及ＨＵ增殖细胞删除法研究了ＢＸＳＢ小鼠脾脏Ｂ细胞的增殖动力学。结果表明，与正常对照相比，ＢＸＳＢ小鼠脾脏Ｂ细胞更新速率明显增高。提示Ｂ细胞更新加速可能是ＢＸＳＢ小鼠外周Ｂ细胞异常增生的原因。

Study on abnormal proliferation of peripheral B cell in BXSB mice

SLE is a disease characterized by abnormal activation and number increase of B cells.The kinetics of splenic B cells in BXSB mice with SLE was studied by in vivo labeling with the thymidine analogue 5 bromo 2 deoxyuridine(BrdU) and hydroxyurea(HU) treatment.Our results demonstrated that the turnover of splenic B cells in BXSB mice with SLE was faster than that in normal controls,and indicated that the higher rate of production and faster turnover of B cells was an important reason for B cell number increase in SLE prone mice.