| GM—CSF在登革病毒感染人单核细胞中的作用 |
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| 引用本文： | 曹艳英 郭辉玉. GM—CSF在登革病毒感染人单核细胞中的作用[J]. 中华微生物学和免疫学杂志, 1997, 17(4): 302-304 |
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| 作者姓名： | 曹艳英 郭辉玉 |
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| 作者单位： | 暨南大学组织移植与免疫实验中心(曹艳英)，中山医科大学微生物教研室(郭辉玉) |
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| 摘 要： | 以正常人外周血和脐带血单核细胞作为登革Ⅱ型病毒（Ｄ２Ｖ）感染的靶细胞，研究了粒细胞巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）对Ｄ２Ｖ复制的影响以及单核细胞感染Ｄ２Ｖ后ＧＭ－ＣＳＦ产生能力的变化。结果表明，ＧＭ－ＣＳＦ能增加Ｄ２Ｖ的复制，Ｄ２Ｖ感染能引起人单核细胞产生ＧＭ－ＣＳＦ，它们的量与Ｄ２Ｖ感染量呈正相关。结果提示，ＧＭ－ＣＳＦ在病毒感染过程中起重要作用。
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| 关 键 词： | 登革Ⅱ型病毒 人单核细胞 粒细胞巨噬细胞集落刺激因子 |
Effect of GM CSF on dengue virus infection in human monocytes |
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| Cao Yanying,Guo Huiyu. Effect of GM CSF on dengue virus infection in human monocytes[J]. Chinese Journal of Microbiology and Immunology, 1997, 17(4): 302-304 |
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| Authors: | Cao Yanying Guo Huiyu |
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| Affiliation: | Cao Yanying,Guo Huiyu.Institute of Tissue Transplantation and Immunology,Jinan University,Guangzhou 510632 |
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| Abstract: | Human monocytes from normal peripheral blood and cord blood could be used as the target cells for dengue 2 virus(D2V) infection.We studied the effect of GM CSF on D2V replication and production of GM CSF by D2V infected monocytes.The results showed that GM CSF could enhance D2V replication in human monocytes,production of GM CSF was increased by D2V infected cells and the level of GM CSF was parallel to D2V infecting dosage.The results suggest that GM CSF plays an important role in dengue virus infection. |
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| Keywords: | Dengue virus Monocytes GM CSF Dengue virus infection |
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