缺血预适应对心肌梗塞的保护作用及其机制

目的：观察心肌缺血预适应对心肌梗塞（ＡＭＩ）的保护作用。方法：选择２１０例ＡＭＩ病例，根据ＡＭＩ前有无心肌缺血、心绞痛将其分为两组。Ａ组有缺血预适应，Ｂ组无缺血预适应，将ＡＢ两组临床资料进行对比分析。结果：Ａ组小面积心肌梗塞的发生率明显高于Ｂ组，而左心衰竭、心律失常的发生率及病死率明显低于Ｂ组，有统计学意义。结论：心肌缺血预适应对ＡＭＩ具有保护作用，主要表现在限制梗塞的扩大，维护了梗塞后心功能，降

PROTECTIVE EFFECT OF ISCHEMIC PRECONDITIONING ON ACUTE MYOCARDIAL INFARCTION AND ITS MECHANISM

Objective:To study the protective effect of ischemic preconditioning on acute myocardial infarction(AMI).Methods:Clinical data of 210 AMI cases were selected.All the cases were divided into two groups according to whether ischemia and angina pectoris existed or not.Group A showed ischemia and angina pectoris before AMI while group B did not.Results:The clinical features in group B were quite different from those in group A:larger infarction size,more freqency of cardiac arrhythmias,poorer left cardiac function,higher mortality rate.The difference between the two groups was statistically significant.Conclusion:Ischemic preconditioning had protective effect on AMI and mainly limited cardiac infarction size.As left cardiac function was maintained after AMI,the rate of cardiac arrhythmias and mortality were decreased.