An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance. |
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| Authors: | B E Henricson R Neta S N Vogel |
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| Affiliation: | Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. |
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| Abstract: | In this report, administration of a recombinant interleukin-1 receptor antagonist protein to mice was found to inhibit induction of colony-stimulating factor as well as induction of early endotoxin tolerance by lipopolysaccharide. These findings provide direct evidence that interleukin-1 is an intermediate in these two lipopolysaccharide-induced phenomena. |
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