某传染病医院11年问药物性肝损伤住院病例状况分析

目的探讨药物性肝损伤（drug-indUeedliverinjury，DILl）在非感染性肝病患者中的分布情况。方法回顾性研究某院2002年1月一2012年12月3848例DILI住院患者的资料，分析年度分布情况、患者性别、年龄及预后。结果DILl患者年住院数由88例（2002年）升至835例（2012年），在非感染性肝病中的构成比由13．19％升至21．52％。10～49岁的患者随着年龄的增加，发生DILI的人数呈上升趋势；50～89岁的患者随着年龄的增加，发生DILI的人数呈下降趋势。〈10、10～19、20～29、30．39、40～49、50～59、60。69、70～79和≥80岁各年龄组DILl患者构成比分别为1．65％、5．11％、12．10％、19．08％、25．45％、20．62％、10．42％、4．58％和0．98％。各年龄组女性构成比分别为30．16％、44．90％、49．46％、55．10％、58．37％、64．28％、58．85％、52．00％和27．78％。药物性肝硬化患者构成比为7．7％，药物性肝衰竭为4．1％，药物性肝炎为88．2％。3848例中总无效死亡率为7．61％，2010年开始DILl无效死亡率呈下降趋势，2012年为2．87％。结论DILl正逐渐成为肝病中的常见病，30。59岁为DILl高发年龄．30～79岁的nTlll患者以奇件为丰。

Analysis of inpatients with drug-induced liver injury in a certain infectious diseases hospital during 11 years

Objective To investigate the distribution of inpatients with drug-induced liver injury （DILI） in inpatients with non- infectious liver diseases. Methods The data of 3848 DILI patients hospitalized fi＇om Jan. 2002 to Dec. 2012, including annual distri- bution, sex, age and prognosis, were analyzed retrospectively. Results The number of DILI inpatients rose from 88 in 2002 to 835 in 2012, and the proportion of DILI inpatients to inpatients with non-infectious liver diseases rose from 13.19% in 2002 to 21.52% in 2012. The number of DILI inpatients aged 10-49 years old increased with age, while that of DILI inpatients aged 50-89 years old decreased with age. The proportions of DILI inpatients aged 〈10, 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, and I〉80 years old were 1.65%, 5.11%, 12.10%, 19.08%, 25.45%, 20.62%, 10.42%, 4.58% and 0.98%, and the ratios of females in respective age groups were 30.16%, 44.90%, 49.46%, 55.10%, 58.37%, 64.28%, 58.85%, 52.00% and 27.78%. The inpatients with drug- induced liver cirrhosis, drug-induced liver failure and drug-induced hepatitis accounted for 7.7%, 4.1% and 88.2%, respectively. The total rate of ineffectiveness and mortality was 7.61%, and the rate of ineffectiveness and mortality had been decreasing since 2010 and was 2.87% in 2012. Conclusions DILI has become one of the common liver diseases. The incidence rate of DILI is higher among the patients aged 30-59 years old, and females account for the largest proportion in DILI patients aged 30-79 years old.