Synthesis of N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of biologically active polypeptide hormone fragments |
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Authors: | HELGA SÜLI-VARGHA KLMN MEDZIHRADSZKY |
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Institution: | HELGA SÜLI-VARGHA,KÁLMÁN MEDZIHRADSZKY |
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Abstract: | N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of α-melanotropin and gastrin fragments were synthesized by the acylation of the peptides with active esters of N-(2-chloroethyl)-N-nitrosocarbamic acid. These compounds are supposed to be antitumor agents of low toxicity and increased selectivity. |
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Keywords: | N-(2-chloroethyl)-N-nitrosocarbamoyl peptides gastrin α -melanotropin |
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