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Synthesis of N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of biologically active polypeptide hormone fragments
Authors:HELGA SÜLI-VARGHA  K LM N MEDZIHRADSZKY
Institution:HELGA SÜLI-VARGHA,KÁLMÁN MEDZIHRADSZKY
Abstract:N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of α-melanotropin and gastrin fragments were synthesized by the acylation of the peptides with active esters of N-(2-chloroethyl)-N-nitrosocarbamic acid. These compounds are supposed to be antitumor agents of low toxicity and increased selectivity.
Keywords:N-(2-chloroethyl)-N-nitrosocarbamoyl peptides  gastrin  α  -melanotropin
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