Type II‘β-bend conformation of tert.-butyloxycarbonyl-L-amino-succinyl-L-alanyl-glycine methyl ester in the solid state期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Type II‘β-bend conformation of tert.-butyloxycarbonyl-L-amino-succinyl-L-alanyl-glycine methyl ester in the solid state

Authors:	S CAPASSO L MAZZARELLA F SICA A ZAGARI

Abstract:	Boc-L-Asu-L-Ala-Gly-OMe crystallizes in the monoclinic space group P2₁ with cell dimensions a = 14.315(3) Å, b = 9.280(2) Å, c = 14.358(3) Å, β= 103.63 (1) d?, V= 1853.4(9) Å³, with two molecules in the asymmetric unit. The conformation of the two molecules is characterized by a type II' β-bend, similar to that predicted earlier by potential energy calculations, stabilized by an intramolecular hydrogen bond. I.r. and ¹H-n.m.r. data show that the folded conformation is also stable in chloroform solution.

Keywords:	aminosuccinyl peptides crystal structure i r n m r peptide conformation succinimide ring conformation β -turn